Quigley (69) and Furyk (68) had solid rounds for a second straight day while Perry shot up the leaderboard after starting the day tied for 73rd.
First-round leader Rocco Mediate (71), Scott Verplank (69) and Brian Bateman (70) began the third round one shot behind the leaders, a negligible difference on a course ripe for low scores.
Tiger Woods and Vijay Singh are not playing the Buick Open for the first time since 2001, good news for the rest of the players competing for the $882,000 winner's check .
Woods (with his wife and baby) and Singh (resting a sore elbow) have combined to win four of the previous five tournaments about 60 miles north of Detroit.
Furyk is the only player to break the stars' dominance at Warwick Hills, winning in 2003. He is shooting for his first victory of the year, 13th of his career. He has shot in the 60s in eight straight rounds at the Buick Open, matching Woods' tournament record, and 35 straight sub-par rounds.
Quigley hasn't finished better than second on the PGA Tour. He was the second-round leader at the Buick Open last year, one shot ahead of Woods, before finishing seventh.
Perry won twice in 2005, but has had to wait to win No. 10 on the PGA Tour.
Quigley was 4 under through 10 holes, giving him a two-shot lead over Furyk, before a lackluster finish ruined his chance to enter the weekend with a cushion.
At a tournament where the past two winners finished 24 under, Quigley said everyone in contention has the same mind-set.
"It doesn't matter if you're leading or not, you have to shoot probably 10 or 12 under on the weekend to have a chance," he said.